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Brain Magnetic Resonance Imaging in 23 Patients with Mucopolysaccharidoses and the Effect of Bone Marrow Transplantation
Ann Neurol 50:79-92, Seto,T.,et al, 2001
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Article Abstract
In two of five patients, the therapeutic effect of bone marrow transplantation (BMT) was remarkable. Both the cribriform changes and the intensity change of the white matter in a MPS VI patient disappeared eight years after the BMT. Slight improvement of cribriform change was noted in one patients with MPS II three years after the BMT. MRS was not sufficient to estimate the accumulation of glycosaminoglycans but was useful for evaluating neuronal damages.
 
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bone marrow transplantation
cerebral cortical atrophy
cisterna magna,enlarged
corpus callosum
corpus callosum,lesion of
hydrocephalus
MRI
MRI,abnormal
MRI,disappearing lesion on
MRI,high signal foci on
MRS
mucopolysaccharidoses
spinal cord,compression of
treatment of neurologic disorder
white matter disease

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